Results backed by clinical research
Experience the initial findings of two clinical trials that examine the efficacy, safety and dosage of two powerhouse MetaPWR products
Understanding Metabolic Health
Various components of metabolic health are either measurable, visible, or detectable. Here’s a graphic depicting the many areas of your life and wellness that are impacted by your level of metabolic health.
You can measure your body mass index (BMI), your weight, and your cholesterol levels.
You can see your skin, your muscle tone, the health of your hair and nails.
You can detect if you’re sleeping well, how good your cognition and energy are. You can detect your ability to perform with your muscles, how strong are they, and how fast they recover.
These are all under the broad scope of metabolic health. It's clear that metabolic health is far more than just metabolism!
Here, you’ll experience the science and preliminary research of key components of the MetaPWR System, including a deep dive into the superstar, proprietary ingredients that make these products second to none.
Research Approach
dōTERRA uses a specific pathway that produces not only the best products, but also the best research in the essential oil industry. There are four pillars of clinical research at dōTERRA: purity, consistency, potency and efficacy. Purity and consistency are essential first steps. If you don’t have them, you can not do clinical research.
Without pure product and consistent chemistry between batches over years, it would be useless to do clinical research on a product because you couldn’t guarantee one year’s results of product to another. Batch-to-batch consistency is required before you can move onto the next steps of the clinical research pathway of potency and efficacy.
Potency and efficacy are proven through human clinical trials. These four pillars are sequential, and if work is done out of sequence, the results are highly questionable and likely, not repeatable.
Clinical Trials of MetaPWR Assist
Let's explore the results of two clinical trials featuring one product in the MetaPWR System – MetaPWR Assist. The first was a potency, or dosage, trial and the second was an efficacy trial.
MetaPWR Assist is vitally important to metabolic health. It’s designed to help us maintain healthy blood glucose levels. When our blood glucose is in the normal range, our bodies, organs, and tissues work together to support the healthy function of each of our body’s systems.
When blood glucose levels are suboptimal, proteins in our bodies oxidize, and they can’t do their jobs effectively. This leads to premature aging and suboptimal metabolism.
Sugar is a definitive enemy in our quest for optimal health.
The ingredients in MetaPWR Assist are specifically designed to help us maintain healthy glucose levels and improve our metabolism.
When we eat food, blood glucose levels rise. That rise in blood glucose signals our pancreas to release insulin. So, in the following graph, the orange arrow shows the peak glucose level, and the grey arrow shows the insulin response.
As insulin rises, glucose levels fall. This is because the insulin signals the glucose to move inside the cells, making it available for energy production. This is the basic process happening inside your body every time you eat.
This is a very elegant process, under very tight control within the body. But you can imagine that we run into trouble if our blood glucose levels are frequently elevated through unhealthy lifestyle choices – like eating too much sugar, too much processed food, or being too sedentary.
In these situations, the pancreas must pump out insulin non-stop. It’s like an engine in a fine sports car. It’s forced to run at top speed with no break – and it gets worn out pretty quickly.
The Breakdown of Carbohydrates
An important step of this process is the breakdown of the carbohydrates we eat into simple sugars. There are specific enzymes in the body that do this job. Without this step, we can’t absorb the carbs that we eat.
What if there was a way to slow down these enzymes so that the carbs we eat aren’t broken down as quickly causing those high peaks in blood glucose levels?
That’s exactly what MetaPWR Assist does! The ingredients in MetaPWR Assist block the function of the enzymes that turn carbohydrates into simple sugars. This leads to decreased blood glucose levels after meals which means that your body doesn’t have to pump out as much insulin in response.
The least amount of insulin our body needs to produce to support healthy blood glucose levels, the better for long term, healthy aging.
The Magic of Mulberry Leaf Extract
Namely, it’s the mulberry leaf extract in MetaPWR Assist that supports this process. It contains aminosugars that bind to the enzymes that break down carbohydrates and block their activity. When this particular activity is blocked, the carbs we eat can’t be absorbed as effectively.
dōTERRA hypothesized that taking MetaPWR Assist before meals would lead to a drop in peak blood glucose levels, and thus in the amount of insulin needed after meals in healthy individuals. This is shown by the dotted yellow line in this graph. If you lower the glucose peak (orange), the insulin peak (grey) should also lower. Two human clinical trials were conducted to test this hypothesis.
MetaPWR Assist Clinical Trial 1
The first clinical trial was a small, single-blind, placebo-controlled, cross-over clinical study to determine potency or dosing, monitor safety markers, and confirm the end points the researchers wanted to do in a larger clinical study. There were 15 participants. Half took a 250mg dose of MetaPWR Assist and the other half took a 500mg dose before each meal. All participants wore a continuous glucose monitor. It’s a little device that works through a tiny sensor inserted under your skin, measuring blood glucose levels every 15 minutes, day and night.
Each participant ate the same high carbohydrate breakfast, stacking the deck a bit, so the researchers could see what the blood sugars were doing throughout the day. Participants took the placebo for a week and the Assist for a week, while eating this tightly controlled breakfast. They ate their regular diet for the rest of the day.
The Results
The MetaPWR Assist showed the ability to smooth blood sugar spikes after eating and it made those peaks and valleys of blood sugar smoother throughout the day, as well. The supplement was well-tolerated by participants and many reported feeling better energy and fewer cravings for high-carb food.
Participants taking the MetaPWR Assist had variations – the difference between the peak and valleys – of 14.3% lower than those taking the placebo.
Most of all, the study found statistical significance with such a small sample size. The difference between groups was statistically significant with a p-value of 0.036.
The study measured the drop in blood glucose after eating to be 12 points difference on average – and even more in some participants. The difference in blood sugar spike after taking two capsules instead of the placebo was p-value of 0.22. This is significance where the study wasn’t even expecting it. This tends to be a good indicator that the effects you’re looking for are really strong.
Additionally, there were differences in those taking the 250mg and the 500mg doses of the Assist. This signifies that there’s flexibility in the dosing and you can feel confident trialing which dose is best for you and your specific metabolic needs.
MetaPWR Assist Clinical Trial 2
The second trial was a larger, longer, double-blind, placebo-controlled, randomized, crossover efficacy trial to confirm the results and seek statistical significance. After conducting the first study, the researchers knew they could see significant improvement in blood sugar levels in healthy participants when they all ate the same thing.
But what about a real-life scenario?
What about giving MetaPWR Assist to people with a wide range of lifestyle choices, eating habits and carbohydrate loads over a much longer period of time?
Would there be the same statistical and clinical significance found?
There were 40 participants total and twenty-six participants completed the entire study with a full set of data. Participants were randomly assigned to take the MetaPWR Assist or the placebo for one month. Then switched to the other for one month. Everyone wore a continuous glucose monitor. The researchers collected biological samples to check for various safety markers.
Remarkably, despite the smaller sample size, researchers gathered and analyzed over 180,000 data points during this two-month study.
The Results
The results were even more impressive and exciting to the research team than the first study, and here’s why.
Not only did they find statistical significance again, in measures of post-meal glucose spikes, and glucose levels throughout the day, they found even higher significance than in Study 1. And this occurred in real-life scenarios without that tightly controlled meal.
What they found was when looking at the peaks and dips of blood sugar after eating, MetaPWR Assist significantly smooths the line compared to the placebo.
This study produced an astounding p-value of 0.001. That p-value means there is a 99.9% probability that the results from the study are due to the efficacy of the product itself and not simply because of chance. This is very rare within the supplement industry and it gives us incredible confidence in the ability of MetaPWR Assist to help regulate blood sugars already in the normal range.
What you’re seeing in this previous image is the type of data collected during the study. On the top, you have the placebo results with high peaks and valleys throughout the day. And the bottom, with the Assist you can see a smoother line with the peaks and valleys, with the average blood sugar dropping 11 points.
This particular graph is the data for just one person. And if you’re a stats person, you’re likely saying, “So what?” and rightly so; however, you need to know that the researchers layered all data within one graph as well and this graph you’re seeing here is, in fact, indicative of the global results of the study.
If we remember that high highs and low lows are what attribute to poor metabolic health, including premature aging, these results are astonishing!
MetaPWR Assist also did not demonstrate any safety concerns across participants.
And there was one final interesting finding in the study. MetaPWR Assist appeared to have a differential effect, meaning, a stronger balancing capability for participants with a greater need. For participants with higher highs and lower lows, the Assist responded in kind, helping them smooth the line significantly. There was a gentler affect within participants whose blood sugars were already close to optimal. This indicates that MetaPWR Assist is a great supporter of a healthy lifestyle and is an integral part of the MetaPWR System as a whole.
Here is a simple recap of MetaPWR Assist:
Understanding MetaPWR Advantage
Let's switch gears now to explore another product within the MetaPWR System – MetaPWR Advantage. With the MetaPWR Advantage collagen product, we are looking to put more years into our lives and close the gap between health-span (your number of healthy years) and lifespan.
This gap has grown so wide for so many people across the planet, but we no longer have to settle for this.
MetaPWR Advantage can slow the signs of aging from the inside out. We now understand that health happens when we connect our metabolic age to our biological age – as these are the things that really determine the length and quality of our health-span.
The Aim of Advantage
MetaPWR Advantage is designed to:
1. support us in the goal of living younger, longer,
2. take the helm of our epigenic influence and biology,
3. assist us in slowing the signs of aging, and
4. positively affect our biological age to extend healthy years.
Full body support – both inside and outside – is available to you through Advantage. And while the process of slowing the aging process is complicated, taking Advantage is not. You simply need to take one sachet in water daily to enjoy the following benefits:
Now, if you want more science, let’s keep going so you can fully understand just how stacked this ingredient deck really is and what makes MetaPWR Advantage unlike any collagen product on the global market.
We’ll start with this holistic view of all ingredients within Advantage. Take a moment to read through and acquaint yourself with these powerful ingredients that work synergistically within your body.
Advantage Framework
Let's organize these ingredients a bit. Here’s a framework to help you understand which ingredients are playing what role in the goal of supporting the aging process from the inside out.
It’s important to note that you can’t simply go to the store, buy these ingredients separately and re-create MetaPWR Advantage. It truly is a unique formulation that works synergistically to outperform all others.
Advantage is your anchor product, giving you the proteins and amino acids you require when your body is building and re-building tissues from cells to skin. You can see that you don’t just have collagen in Advantage. You have NMN, NADH and resveratrol – three key ingredients designed to complement and improve the utilization of the ingredients within Advantage.
We can also address the skin’s health and elasticity from the outside with ingredients like liposomal vitamin C, red orange complex, sea buckthorn and rose apple extract.
With this inside out approach, powered by these ingredients, Advantage helps create vitality within our bodies that starts within and shows on the outside.
It’s renewal that you can see and feel.
What is Collagen?
Collagen is the most abundant protein in the human body. There are 28 different types of collagen that make up bones, skin, nail, cartilage and tendons. The production of collagen declines with age. We see the most obvious affects of the aging process on our skin, yet this process truly begins on the inside.
Peptides: The Regular Ol’ Collagen
Most collagen products contain collagen peptides. These are large proteins, the “raw goods” so to speak, that when you ingest them, your body could then potentially make hair, skin, nails, etc. You can think of these peptides as regular ol’ collagen.
They are huge chains that the body must break down, or hydrolyze, into a form that the body can use. The bioavailable forms are called tripeptides. This process is indiscriminate and you can only hope that the collagen peptides you ingest are being used towards your specific health goals – but there’s no guarantee.
Tripeptides: The Superior, Bioavailable Form
A superior form of sourcing collagen is to start with the tripeptides themselves, and this is what you’ll find in Advantage. They are “predigested” or hydrolyzed, using a specific enzyme called protease. The protease comes along and snips that large peptide molecule into smaller pieces called fragments, or tripeptides. Not only does this provide better absorption, more importantly, tripeptides are specific peptides that do specific jobs – the ones you care about most.
Advantage is 70% tripeptides which is unheard of in the marketplace. It provides 12x’s better absorption than non-hydrolyzed collagen. One sachet is Advantage is 3 grams of tripeptide collagen which equates to a 36g serving of the regular stuff.
Understanding the Role of Tripeptides
There are nine forms of tripeptides in Advantage. On the following slides, they are grouped for you by their general function so you can understand which tripeptides support healthy skin, aid us in the aging process, and promote the structural health of your body.
On the first slide below, you’ll see the different types of collagen tripeptides that deal specifically with skin health, giving you the elasticity, hydration and firmness that you’re looking for.
The next grouping works with aging, cellular health and normal brain aging. This is a different cluster of tripeptides that will do these specific jobs for you.
And the final grouping is that of structural health. Here you’ll see there are several tripeptide building blocks available to you in Advantage to help you maintain the health and wellness of your bones, cartilage, joints, and connective tissue.
Peptides vs. Tripeptides
So, it’s important to ask, what am I getting with the tripeptides in Advantage vs. regular un-hydrolyzed collagen peptides in other products on the market?
Here’s a comparison for you that makes it easy to see:
Additional Notes On This Comparison
Our tripeptides come from a proprietary marine source in Italy. Proprietary means that they only sell to dōTERRA and no other collagen manufacturers. You really are getting a unique product available only through dōTERRA's Advantage.
Advantage doesn’t contain emulsifiers. Emulsifier are food additives used to stabilize processed foods and harm the balance within the gut. Omitting the emulsifier is an important aspect towards your long-term gut microbiome health.
We aren’t shipping water which has multiple benefits. First, not shipping water decreases the carbon footprint of the product significantly. In addition, collagens that are sold with water have been pasteurized and often contain junk sugars or juices. Not so with our Advantage. Simply add the Advantage powder to room temp or cold water – never hot – when you’re ready to drink. Mix, shake, or stir vigorously to activate, and enjoy.
Advantage Ingredient Spotlight: NAD
NAD takes MetaPWR Advantage into another stratosphere. There’s simply nothing like this available to you outside of Advantage.
NAD is a master molecule that keeps your cells younger, longer. It declines as we age (beginning in our early 20s) and without it, you’d literally die in seconds. It’s that important. Our cells need it to produce energy and to activate proteins that support healthy DNA.
Bottom line: a drop in your NAD levels is the actual aging process, attributing to a decline in metabolic health. You need generous levels of NAD in your body to close the gap between health-span and lifespan.
Here’s a graphic version to help you understand NAD better:
Bridging the NAD Gap with NMN
To fix this problem of a decline in NAD, it’s critical that you understand the precursor to NAD, called nicotinamide mononucleotide. We’ll shorten that to NMN.
You don’t make NMN in your body – it must come from an outside source (aka MetaPWR Advantage) – and it helps you manufacture copious amounts of NAD. And remember, NAD is critical to help bridge the gap between health-span and lifespan.
In pure brilliance, Advantage formulators also added resveratrol. The NMN to NAD process is accelerated because of the resveratrol in Advantage.
In a clinical study that’s yet to be published, initial findings indicate a 20% increase in NAD levels after just two weeks of Advantage consumption. The implications of this are simply astounding. Once the study is published, you’ll find it here on this page – stay tuned!
Exciting Findings
While the clinical studies conducted with the MetaPWR System are still in their early stages, it’s clear by the initial findings that there is scientific evidence to support the user testimonials and anecdotal evidence shown here on this website and within the global Facebook communities.
Metabolic science is complicated to most people. And while people like Rosie here, pictured in her before-and-after pictures below, may not fully understand the pathways and science behind MetaPWR, she doesn't have to to become living proof of the system’s effectiveness.
Rosie’s physical transformation is easy to see, yet that isn’t the only benefit she received from MetaPWR. She also reported the following results from her own personal 30-day trial that are far more than just skin deep.
Rise & Thrive
It’s time to discover for yourself the power within the MetaPWR System and live your own story of improved health and well-being.
DISCLAIMER: *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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